This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
TABLE OF CONTENTS
TOXICOLOGY, "OMICS" TECHNOLOGIES, AND TOXICOGENOMICS: A PRIMER (Darrell R. Boverhof and B. Bhaskar Gollapudi).
INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT (Irene Baskerville-Abraham, Alison Willis, Bernard Gadagbui, and Lynne T. Haber).
PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS TO RISK ASSESSMENT: EARLY EXPERIENCE, CURRENT DRIVERS, AND A PATH FORWARD (Darrell R. Boverhof, David R. Geter, B. Bhaskar Gollapudi, and Heli Hollnagel).
APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF TOXICOGENOMICS DATA (Zhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, and Leming Shi).
GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN CARCINOGENESIS (Jiri Aubrecht and Ebru Caba).
APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS (Mark R. Fielden).
GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY (Jorge M. Naciff and George P. Daston).
STUDYING ORGAN-SPECIFIC TOXICITY USING GENE-EXPRESSION PROFILING (M. Ann Mongan and Hisham K. Hamadeh).
TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS (Cliona M. McHale, Luoping Zhang, Alan E. Hubbard, and Martyn T. Smith).
TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT (Daniel L. Villeneuve, Dalma Martinovi´c, and Gerald T. Ankley).
ANALYSIS OF TRANSCRIPTOMIC DOSE–RESPONSE DATA FOR TOXICOLOGY AND RISK ASSESSMENT (Russell S. Thomas, Longlong Yang, Harvey J. Clewell, and Melvin E. Andersen).
TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS, APPLICATIONS, AND CHALLENGES (Alan Dombkowski and J. Craig Rowlands).
TOXICOGENOMICS AND ANIMAL ALTERNATIVES (Anne S. Kienhuis, Joost H. M. van Delft, and Jos C. S. Kleinjans).
TOXICOGENOMICS AND THE REGULATORY FRAMEWORK (Kathryn Gallagher, Federico M. Goodsaid, David J. Dix, Susan Y. Euling, Melissa Kramer, Nancy E. McCarroll, Julian R. Preston, Philip G. Sayre, Banalata Sen, Douglas C. Wolf, and William H. Benson).
STANDARDIZATION OF GENE-EXPRESSION INFORMATION FOR THE SAFETY EVALUATION: ACTIVITIES IN JAPAN (Ken-ichi Aisaki and Jun Kanno).
APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION (Lois D. Lehman-McKeeman and William R. Foster).
REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS BIOLOGY APPROACH (Sarah N. Campion and Kim Boekelheide).
DARRELL R. BOVERHOF, PhD, is a Senior Toxicology Specialist at The Dow Chemical Company where he leads research programs on respiratory allergy and sensitization, nanotoxicology, and toxicogenomics. Dr. Boverhof has authored or coauthored numerous peer-reviewed publications, review articles, and book chapters in the area of toxicogenomics and serves on the editorial board of the journal Toxicological Sciences.
B. BHASKAR GOLLAPUDI, PhD, is the Scientific Director of Mammalian Toxicology at The Dow Chemical Company's Global Toxicology & Environmental Research Laboratory. Dr. Gollapudi has authored or co-authored more than 80 scientific publications. He is an Associate Editor of the journal Toxicological Sciences and is currently serving as an adjunct Associate Professor of Toxicology in the Department of Public Health at the University of Michigan.